3quarksdaily: Cancer screen yields drug clues

Cancer screen yields drug clues

From Nature:

Two compendiums of data unite genetic profiling with drug testing to create the most complete picture yet of how mutations can shape a cancer?s response to therapy.?The results, published today in Nature^{1, 2}, suggest that the effectiveness of most anticancer agents depends on the genetic make-up of the cancer against which they are used. One study found a link between drug sensitivity and at least one mutation in a cancer-related gene for 90% of the compounds tested.

Lab-grown cancer cells are a mainstay of research into the disease. The two projects catalogue the genetic features of hundreds of such cell lines, including mutations in cancer-associated genes and patterns of gene activation. They then match these features with how the cells respond to approved and potential drugs. ?This is a very powerful finding,? says Tom Hudson, president of the Ontario Institute for Cancer Research in Toronto, Canada, who was not affiliated with the work. ?It could provide valuable information for designing clinical trials, and lead to more focused and less expensive approaches to drug development.?

More here.

Posted by Azra Raza at 06:18 AM | Permalink

Source: http://www.3quarksdaily.com/3quarksdaily/2012/03/cancer-screen-yields-drug-clues.html

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Poop-to-power tech begins to smell reasonable

9 hrs.

John Roach

Researchers have created a microbial fuel cell that can convert about 13 percent of the energy in raw sewage into electricity as it helps clean up municipal wastewater.

The technology under development is an improvement from two percent efficiency just a year ago, researchers at the J. Craig Venter Institute?reported Wednesday at the annual meeting of the American Chemical Society.

?That actually puts us in a realm where we could produce a meaningful amount of electricity if this technology is implemented commercially,? Orianna Bretschger, who presented the development, said in a news release.

The idea is to use the electricity generated from the microbial fuel cell to clean up wastewater for no additional energy costs. Some estimates put the energy use of wastewater treatments plants at two percent of overall consumption in the U.S.

The team?s microbial fuel cell relies on naturally-occurring microbes in sewage that produce electrons and protons as they digest organic waste. While this isn?t the first or only microbial fuel cell under development, ?its efficiency is, as Bretschger said, ?a giant step in the right direction.?

What?s more, the fuel cell cleans up about 97 percent of the organic matter in wastewater. That?s not clean enough to drink ? need 99.9 percent for that ? but the fuel cell does a lot of the work, meaning less electricity is required for the other steps.

--Via Yale Environment 360

John Roach is a contributing writer for msnbc.com. To learn more about him, check out his website?and follow him on Twitter. For more of our Future of Technology?series, watch the featured video below.

Source: http://www.futureoftech.msnbc.msn.com/technology/futureoftech/poop-power-tech-begins-smell-reasonable-596938

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Feds, 5 states to push for Great Lakes wind farms

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Source: http://news.yahoo.com/feds-5-states-push-great-lakes-wind-farms-070649644.html

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5 Tips To Find The Best Online University For You

There are people who don?t have the time and commitment to enroll in a regular university so what they can do is get a university education online. Today there are countless options for getting yourself an online education, depending on your specific needs and goals. Therefore making the right choice that will be most suited to your schedule and learning style as well as the course itself is of prime importance.

Be clear about your needs

When it comes to getting an online education, different people have different needs. You need to do some introspection first before you consider your options in order to determine if what kind of education you?re looking and if it will fit your routine and the time and effort you?re willing to spare.

Investigate your options

In the Internet, there are a lot of online education offers for every conceivable purpose. That?s why it?s important to take time to gather information about the options that would suit you. Most schools provide free information kit on their education programs that can help you get a better idea of what?s in store if you choose to enroll with any of them. You have the option of conducting searches according to the type of courses you are interested in and colleges based on locations. Having a clear idea of the program being offered is important before investing your money and time into any of them.

Watch out for scams

When doing your searches for the right course, there is no dearth of scams to be wary off with all the offers on the Internet. Steer clear of any course you?ve heard about from an spam e-mail. Fake degrees and credentials are plentiful and you?ll only be wasting your time, effort and money if you go with one of them.

Find accreditation

An important thing to look for is accreditation of the institute or school you enroll in. The degree you?ll be earning needs to be recognized by your employers, and this is why you?re pursuing further education to advance your career.

What about the facilities that are offered?

Different online courses have different facilities to offer their students. Many offer services like tutoring, reference links, library access, technical assistance, discussion threads, interaction with fellow students and a variety of other features. You can benefit on certain kinds of study aids and so your choice should be based on the facilities you can avail when you enroll for a course.

If you?ve been injured, your auto accident attorneys Asheville North Carolina can help protect your rights and claim the compensation you deserve. Let a winning injury lawyer Asheville fight for you while you move on with your life.

Tags: culture, education, online, online education, reference, Society

Source: http://nativepulseradio.com/5-tips-to-find-the-best-online-university-for-you/

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How To Stop Snoring And Get A Good Night's Sleep ? Article ...

Many people have the problem of snoring when sleeping. This causes a lot of discomfort with their partners, contributing to poor rest for both individuals. For this reason, lots of individuals are searching for remedies to stop snoring. Thankfully, there are various ways to fix the problem of snoring.

Lubricating your nasal passage is one of the best ways to address the problem. A person snores when there?s a vibration in the nasal passage. The vibration inside the nasal passage is caused as a consequence of illness like the flu and colds which obstruct the nasal passage. When the nasal passage gets clogged, individuals are inclined to keep their mouth open in order to aid breathing.

When the mouth is kept open for breathing, an increased quantity of air passes inside which in turn dries the tissues and membrane inside the nasal passage. If these tissues get dry, they give rise to noisy vibrations and disturbances that are referred to as snoring. By simply lubricating the nasal passage, the possibility of snoring is minimized to a great extent.

Sleeping in a supine position is a second strategy for dealing with snoring. As holding the mouth open contributes to noisy disturbances, it?s advisable to keep your mouth closed while sleeping. Sleeping in a supine position or on your stomach is very helpful to stop snoring. Over a certain period of time, the noise and disturbances produced while sleeping disappear.

The use of a nasal separator is an additional powerful method of reducing snoring. The separator is situated in each of the nostrils of a person. It aims at lifting up the nostrils to allow easy passage of air through the nasal passage. Once the air passes clearly through the nasal passage, the likelihood of noise and vibrations will be cut down.

Similarly, the use of nasal strips is an additional strategy for minimizing the snoring . Nasal strips work in the very same way as a nasal separator. These types of products are frequently utilized by people who suffer from the problem. Lots of people have observed encouraging results by making use of them.

These helpful strips are conveniently encountered in a lot of stores in your area. A lot of companies make these products which offer excellent results to stop snoring. The web is often the top place to buy these products. Browse online with suitable keywords and you?ll come up with various brands. Check out online reviews concerning the different products to ensure the quality and efficiency of the product. Evaluate product features and costs, and shop at reputed retailers. Finally, buy the product that promises the desired benefits without the need of causing a major burden on your finances.

Are you interested in trying the My Snoring Solution chinstrap? Be sure to visit I Can?t Sleep At Night for a SnoreEzzz pillow review.

Source: http://articlesquadron.com/health-fitness/sleep-snoring/how-to-stop-snoring-and-get-a-good-nights-sleep

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You Be The Judge ? He Says, She Says ? By USFSB.com

HE SAYS:

My career practicing law, particularly, since it was concentrated in the area of litigation and trial work, involved a lot of writing and public speaking.?? The writing was serious, well researched, and technical works on legal issues affecting my clients and usually took the form of affidavits, memorandums of law, and briefs.? Even though the subject matter was weighty, the writing also needed to be interesting, engaging, and, most of all, persuasive.? After all, the point of it all was to convince a Judge that my client?s position was correct and that my opponent was wrong.

For me, the best part was that I would receive the ultimate critique of my efforts in the form of an Opinion or Decision from the Court.? This would let me know, in no uncertain terms, whether or not what I had written was persuasive enough and good enough to win the case for my client.? There is no greater gratification then when you have articulated your point of view well enough to persuade a Judge to decide in your favor.?? Likewise, there is no greater frustration then when you fall short and lose.

When I came to USFSB there was very little opportunity for any creative writing until I started to write my articles for USFSB?s Newsletter.? Even then the nature of our Newsletter did not lend itself to very much in the way of creativity since most of my articles were just meant to inform our Members of our products or services.

It was not until I started to write my blog postings that I finally came full circle and had the opportunity to be as creative as I wanted to be in my writing efforts and my choice of topics.? The difference, however, is that I do not get the same definitive level of feedback and, certainly, there is not the same kind of validation as I would receive when writing in my law practice.

Now, my writing goes off into the nebulous world of the Internet and there is no way of knowing, for sure, what impact it is having on those who may be reading my blog postings.?? In any event, I am having a lot of fun with this creative outlet even if I am not going to get a winning decision from a Judge.?? So, instead, you be the judge.

On Wednesday, Joe makes some observations that may have a ring of familiarity to some people in ?Sound Familiar??.?????????????

WHAT DO YOU SAY?

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Be the first to like this post.

Source: http://usfsbblog.wordpress.com/2012/03/26/you-be-the-judge/

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How To Market For Your Health And Physical fitness Enterprise Via ...

A lot more than at any time ahead of businesses, businesses, health and fitness facilities, weight loss products, and weight loss facilities are all competing in opposition to one another for the proper to say they have got the most important supporter or consumer base of all their rivals. Levels of competition in the health and fitness fields is hard, and providers will need to search out more inventive techniques to ascertain by themselves and set them apart from opponents. Among the best, new approaches to aiding minority and perhaps massive name companies obtain and maintain their recognition titles is as a result of the usage of content producing services. Absolutely everyone turns to the World wide web at this time for any type of concern, inquiry, and even a simply just curiosity, and getting a website that has about date articles may also help your business to grow and prosper greater than you actually imagined it could ahead of.

Companies that supply content composing services can assist your health and physical fitness company keep its website up-to-date and refreshing, with ideal keyword phrases and optimal SEO to deliver in more traffic (a.k.a. much more potential prospects). Articles crafting services aid to optimize your website to catch the attention of the right kind of individuals towards your service at the ideal time they?re trying to find out facts that will help them reply their queries.

Businesses which provide articles composing services operate with health and fitness organizations to evaluate their precise brand name and message, the different types of merchandise and services they offer, and the kind of people these are trying to appeal to. The moment the foundation of a health and physical fitness company is recognized, then freelancers can begin to deliver content crafting that draws the right kind of potential customers; keeping them engaged in your business? website, marketing your services in an intriguing way, and convincing them to try out you above all of your current competition.

Information writing services are helpful particularly to the health and fitness market as they will help to increase a compact business and current market it via the manipulation of search engines, to make it obtainable to huge quantities of individuals. World-wide-web marketing is compared with almost every other sort of regular marketing for the reason that with websites to market a unique company?s services, industries are now on a lot more of an equal plane with each other. Each and every company in the health and fitness industry now have the entry to the suitable resources to assist greater outline them from their competitors.

This is when material composing gets to be very crucial; every business has the entry to those resources, but the ones who essentially implement them are the major gamers in their subject. The most effective companies inside of the health and health and fitness area have outsourced their articles writing services to qualified corporations who know how to write online material that should entice shoppers and deliver internet websites to the best of search engines. These identical businesses that have invested in subject material producing have invested a lot less on advertising and marketing and have experienced a important leap in their revenues and final results.

The bottom line is the fact investing in content crafting services is a main assist to the on the web marketing, and can also aid to decreased your expenses and optimize your ROI by reducing the need to have for a great deal of regular marketing.

Source: http://www.camarenastamp.com/how-to-market-for-your-health-and-physical-fitness-enterprise-via-content-material-producing-services/

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Intestinal inflammation keeps Detroit Mayor Dave Bing in the hospital

Detroit Mayor Dave Bing will remain in Henry Ford Hospital for further observation, according to a statement just released from the mayor?s office.

Bing?s Chief of Staff Kirk Lewis said the 68-year-old mayor has ?a commonly diagnosed, non-life-threatening condition."

?He continues to rest comfortably,? Lewis said earlier today. ?The mayor is alert, upbeat and tells me he?s ready to return to the office.?

The release did not indicate when the mayor would get the OK to go home.

Bing, 68, spent the night in the hospital after being diagnosed with an inflammation of the intestine, his chief of staff Kirk Lewis said this morning in a statement.

?I spoke with Mayor Bing late this afternoon. He indicated he would remain in the hospital for further observation,? Lewis said. ?He continues to be upbeat and rests comfortably.?

Bing was hospitalized Thursday after feeling discomfort after a morning visit to the dentist.

On WJR-AM (760) this morning, host Paul W. Smith said he spoke to Bing by telephone Thursday night and Bing told him: ?They think I might have a bit of colitis.?

Colitis is an inflammation of the large intestine, or colon.

Lewis said inflammation of the intestine is a commonly diagnosed condition affecting more than half of Americans over 60 years old.

Source: http://www.freep.com/article/20120323/NEWS01/120323008/1001/rss01

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EU slaps sanctions on Assad's wife, relatives

BRUSSELS (AP) ? Officials say that the EU foreign ministers have slapped sanctions on the wife and other close relatives of Syrian President Bashar Assad in a continuing attempt to stop the violent crackdown on opposition.

They said four members of the Assad family and eight government ministers have been targeted in the latest round of sanctions. All three officials spoke on condition of anonymity to discuss a decision will be announced later Friday following the foreign ministers' meeting in Brussels.

Asma Assad, 36, was born in London and has British citizenship, and an EU official said that likely meant she could not be banned from travel to the U.K.

The U.N. estimates that more than 8,000 people have been killed since an uprising began in Syria a year ago.

________

Raf Casert contributed to this report.

Follow Don Melvin on Twitter at http://twitter.com/Don_Melvin

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

BRUSSELS (AP) ? The wife of Syrian President Bashar Assad will be hit with a travel ban and have her assets in the EU frozen, a European Union official said Friday.

A total of four members of the Assad family, along with eight government ministers, will be targeted in the latest round of sanctions aimed at stopping the violent crackdown on members of the Syrian opposition, the official said. He spoke on condition of anonymity to discuss a decision that will be taken later Friday by EU foreign ministers meeting in Brussels.

Asma Assad, 36, was born in London and has British citizenship, and the EU official said that likely meant she could not be banned from travel to the U.K.

British Foreign Secretary William Hague said it was very important to increase pressure on the Syrian regime.

"Their behavior continues to be murdering and totally unacceptable in the eyes of the world," he said on his way into the meeting.

Austrian Foreign Minister Michael Spindelegger said the sanctions should target "the family of Assad ? his wife and his closest relatives. It is necessary."

Last week, Britain's The Guardian newspaper released thousands of emails purportedly from Bashar Assad's private account. They showed him taking advice from Iran on how to handle the uprising, joking about his promises of reform and bypassing U.S. sanctions to shop on iTunes.

The U.N. estimates that more than 8,000 people have been killed since the uprising began a year ago in a cycle of attack and reprisal.

________

Raf Casert contributed to this report.

Follow Don Melvin on Twitter at http://twitter.com/Don_Melvin

Source: http://news.yahoo.com/eu-slaps-sanctions-assads-wife-relatives-100329982.html

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Evidence for Flowing Water on Mars Grows Stronger

News | More Science

Liquid remains the leading explanation for newly discovered streaks on Martian slopes

By John Matson ?| March 23, 2012

LINING UP: Recurring slope lineae at Horowitz Crater on Mars may be the tracks of fluid flowing through the soil. Image: NASA/JPL/University of Arizona

THE WOODLANDS, Tex.?Today's Mars is a frigid desert, a place where water?the key to life as we know it?has gone into hiding. Whatever water may have once existed on Mars in rivers, lakes or even oceans is now frozen into ice caps, locked up in hydrated minerals or buried in debris-coated glaciers.

But last year compelling evidence emerged that when conditions are right, salty brines may persist to this day in liquid form at midlatitude regions on Mars. Alfred McEwen of the University of Arizona and his colleagues found tracks in high-resolution imagery that looked like liquid flowing downhill. The tracks appeared annually during the warmer Martian months on equator-facing slopes, extended downhill and then faded as temperatures dropped once again. One tantalizing interpretation was that the streaks were caused by briny water melting and seeping downhill through the soil.

At the annual Lunar and Planetary Science Conference being held here this week, the researchers provided an update on their search for and analysis of the mysterious features, which they call recurring slope lineae, or RSL. Not only have they more than doubled the count of known RSL but they have been unable to devise a good explanation that does not involve the presence of liquid water.

"No one has come up with alternative models that they believe," McEwen says. "Nor have we." Lujendra Ojha, an Arizona undergraduate student who has done much of the heavy lifting in identifying RSL in imagery from the High Resolution Imaging Science Experiment (HiRISE) camera on the Mars Reconnaissance Orbiter, announced in a talk at the conference that he and his colleagues have now confirmed RSL in 15 locations, up from seven when the features were first announced in a 2011 Science paper. Probable RSL have been identified on 23 additional slopes, but they have not yet been shown to recur year after year. "There's more there that we're going to find," McEwen says.

Other phenomena that have pointed to liquid water on modern-day Mars have plausible explanations involving only dry processes, McEwen notes. Streaky slopes closer to the equator, for instance, do not seem to display the seasonality that would be expected of melting and could simply be tracks from boulders rolling downhill. "In all these cases, you can explain the observations without liquid water," McEwen comments. "You have to favor the nonwater models if you can make it work. For the RSL, we can't make it work."

Support for the liquid-water explanation is coming from studies of arid, frigid regions here on Earth. In another talk at the conference, Joe Levy of Oregon State University compared RSL to similar-looking features caused by saline groundwater seeping downhill through the soil in Taylor Valley in Antarctica. Using satellite observations of Antarctic water tracks, Levy and a colleague found that they could estimate the soil's permeability from orbit by measuring how the tracks propagated downhill. And that estimate agreed reasonably well with the actual soil properties, which Levy and his colleagues have measured in field studies. "For flowing water features that darken the surface, it turns out you can do hydrogeology from orbit, which sure beats hiking," Levy said.

Applying the same calculations to Mars, he concluded that the RSL could be explained by brines if the slopes had the permeability of sand or silt. That matches the kind of soil expected to prevail at the sandy RSL sites. In other words, whatever is moving down the Martian slopes behaves as liquid would in that environment. "The RSL and the [Antarctic] water tracks are both flowing like water through sediment," Levy said. "If it moves like water, it may very well be water."

Source: http://rss.sciam.com/click.phdo?i=e7c0c2041ab0bfe176c36f75c4537dd2

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Video: Oil Shock & Gas Tax

CNBC's Sharon Epperson reports oil spiked past $108 on Friday, and research from Citi shows North America could become the fastest growing oil and gas region in the world within the next decade. Also, debating whether taxing big oil will bring down pri...

Source: http://video.msnbc.msn.com/cnbc/46840709/

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Prometheus Patents Struck Down, 9-0: Mayo Collaborative Services ...

In a strong rebuke to the Federal Circuit, a unanimous U.S. Supreme Court held?(pdf), on March 20, 2012, that Prometheus Laboratories? claims to methods of administering drugs to treat gastrointestinal autoimmune diseases do not meet the patentable subject matter standard of section 101 of the Patent Act.? The representative claim quoted by the Court recites, ?A method of optimizing therapeutic efficacy for treatment of an immune-mediated gastrointestinal disorder? comprising two steps: (a) administering one of a class of drugs (thiopurines) and (b) determining the level of a specified metabolite, ?wherein? a level below a given threshold ?indicates a need to increase the amount of said drug subsequently administered? [to improve efficacy], and a level above the threshold ?indicates a need to decrease the amount of said drug subsequently administered? [to avoid toxicity].

History of the Case. Mayo originally bought and used Prometheus test kits that employed the patented method, but it then decided to sell and market its own test, which was similar, but not identical.? Prometheus sued for patent infringement.? The district court found that Mayo?s test would infringe the Prometheus patents, but it then held the patents invalid as essentially claiming unpatentable laws of nature:? in this case, the relationship between the levels of the specified metabolite and the efficacy or toxicity of the relevant drugs.

The Federal Circuit reversed this decision in 2009, finding that the claims satisfied its then-controlling machine-or-transformation test.? Both the administering and determining stages, the court held, brought about a transformation of the patient?s body.? In the summer of 2010, while a Prometheus cert. petition (a request for Supreme Court review) was pending, the Supreme Court decided Bilski v. Kappos, a case involving a patent on a method of commodities hedging.? In a set of murky opinions, the Court held that the machine-or-transformation test was not the exclusive test of subject matter eligibility for method claims, but it could be helpful in appropriate cases.? Immediately thereafter, the Court ordered the Federal Circuit to reconsider its Prometheus opinion in light of Bilski.? In an opinion that might be described as perfunctory, the Federal Circuit held once more that the Prometheus patents comprised statutory subject matter, and the Supreme Court granted cert.

The Supreme Court?s Reasoning.?The Court?s opinion?(pdf) focuses on the difference between claims to laws of nature themselves and claims to specific applications of such laws: the former fail the section 101 subject matter test, while the latter pass.? The laws of nature involved here are the ?relationships between concentrations of certain metabolites in the blood and the likelihood that a dosage of a?? thiopurine drug will prove ineffective or cause harm.?? The legal question then becomes, ?do the patent claims add enough to their statements of the correlations to allow the processes they describe to qualify as patent-eligible processes that apply natural laws???For all nine members of the Court, the answer was a clear no.

The?Court?s analysis of the claims went through four steps.? First, it observed, the administering step just defines ?the relevant audience??doctors who treat patients with thiouprine drugs.? Second, ?the ?wherein? clauses simply tell a doctor about the relevant natural laws.?? Third, the determining step does not specify any particular process, but merely invites doctors ?to engage in well understood, routine, conventional activity.?? And fourth, ?to consider the three steps as an ordered combination adds nothing to the laws of nature that is not already present when the steps are considered separately.?? In sum, ?the three steps simply tell doctors to gather data from which they may draw an inference in light of the correlation.?? They ?are not sufficient to transform unpatentable natural correlations into patentable applications of those regularities.?? To allow such a patent could ?inhibit further discovery by improperly tying up the future use of laws of nature.?

What Do We Learn??The first point is that section 101 is alive and well as the first test of patentability.? Some recent Federal Circuit opinions have suggested that section 101 can and should be avoided in most cases, leaving the work of evaluating patents to sections 102 (novelty), 103 (nonobviousness), and 112 (written description).? The Court explicitly rejects that approach, refusing to let section 101, with its law of nature prohibition, become ?a dead letter.?? So the Patent Office and the courts will continue to have to make an initial determination of whether an invention comprises statutory subject matter, independent of whether it satisfies the other criteria of patentability.? Nonetheless, the language quoted above about ?well understood, routine, conventional activity? suggests that novelty and obviousness have some relevance to subject matter eligibility, despite loud protests that this conflates section 101 with issues presumably assigned to 102 and 103.

Second, although this opinion is light years ahead of Bilski in terms of clarity, it is still hard to be absolutely certain of what the subject matter test for method patents is.? We know?from the last paragraph of the opinion?that patents that ?effectively claim the underlying laws of nature themselves? are invalid.? Another version of this is that a survivable claim must ?differ significantly from a claim that just said ?apply the algorithm.?? But just how to identify such a claim is a more difficult issue.? We know that a claim structured just like Prometheus?s is invalid: that is, a claim that involves nothing more than gathering data that may provoke an inference based on a law of nature (for example, maybe, the claims upheld by the Federal Circuit on August 31, 2011 in Classen Immunotherapies, Inc. v. Biogen IDEC?).? Some additional application of the law of nature is required?but how much?

The Court rejects ?simply appending conventional steps, specified at high level of generality, to laws of nature.?? It expresses particular concern about claims so broad as to ?seek pre-empt the use? of the law of nature.? But it gives little affirmative guidance about how specific the application of the law must be, declining to speculate on precisely what additional limitations might have saved the Prometheus claims before it.

Impact on Myriad??There have already been a lot of questions raised about the impact of Prometheus on the Myriad litigation, in which a cert petition is still pending in the Supreme Court.? Does this new decision make it more or less likely that the Court will take Myriad? Does it suggest a likely outcome if the Court does take it?

Before speculating about these questions, it is important to remember that the Federal Circuit decision in Myriad addressed three separate sets of patent claims: (1) the court upheld (with a partial dissent) Myriad?s product claims on cDNA and isolated DNA; (2) the court also upheld Myriad?s claims to methods of screening potential cancer therapeutics by analyzing growth rates of cells with altered BRCA genes in the presence or absence of the treatments; but (3) the court rejected Myriad?s claims to methods of analyzing BRCA gene sequences and comparing those with cancer-predisposing mutations to normal sequences. The cert petitions filed by both sides do not address the methods claims (only the product claims and the highly technical standing issue), but the Supreme Court could order briefing and argument on any aspect of the case.

The Prometheus decision says nothing about gene product claims, so is irrelevant to issue (1) in Myriad. But it says a lot, obviously, about method claims that bear at least some structural similarity to those in Prometheus.? So does Prometheus indicate that the Court is more or less likely to review those method claims? (Warning: anyone who claims to have inside information about pending Supreme Court decisions is lying?Court security makes the old KGB look like a sieve.) Our guess (and it?s little more than that) is that the issuance of Prometheus makes it less likely that the Court would review the Myriad method claims.? It has just issued a unanimous and?by the standards of Supreme Court patent cases?relatively clear opinion on generally similar medical methods.? History suggests that is unlikely to want to revisit that topic the very next year.? Prometheus itself is an obvious exception, of course, coming right after Bilski. But the Court may have realized how unhelpful its fractured Bilski opinion was, and all of the justices apparently believed that the Federal Circuit had either failed to understand it or chosen to ignore it.? And the history of Prometheus suggests a possible pathway for Myriad: that the Supreme Court would grant cert, but (with respect to the method claims) for the limited purpose of vacating the Federal Circuit?s opinion and ordering reconsideration in light of Prometheus.

But if the Court does decide to review Myriad (or if the Federal Circuit is ordered to do it over), does Prometheus help us to predict the outcome?? The method claims that the Federal Circuit rejected ((3) above) are hard to distinguish from those in Prometheus: doctors gather information and make a straightforward comparison, using basic genetic knowledge.? Those claims are likely to be rejected once again.? The drug-screening claims that were upheld ((2) above) are a closer call.? If the ?algorithm? is the protocol for comparing the effects of treating or not treating cell lines, then ?do the patent claims add enough to their statements of the correlations [or algorithm] to allow the processes they describe to qualify as patent-eligible processes that apply natural laws??? There is a good bit of practical application going on here: cell lines must be grown and drugs applied (or not) before a judgment is made.? It looks more like a real-world pharmaceutical process than a broad statement of an algorithm.? For that reason, it seems more likely than not that this category of method claims would be upheld once again under section 101.

Conclusion. We now know considerably more about the Supreme Court?s views on methods than we did after the worse-than-useless Bilski opinion.? It is refreshing to these observers that the Court dove right back into method patents in an apparent effort to rectify the damage it did in Bilski (and there?s also some entertainment value in the revival of the Supreme Court-Federal Circuit tension that seemed to have abated a bit). But it also seems unlikely that the Court would go back to the method issue immediately, so we doubt that it will take that part of Myriad, except for the limited purpose of remanding to the Federal Circuit for reconsideration.

In terms of impact on the marketplace, there is, of course, serious impact if your business model depends on patents just like these (e.g., if you are Dr. Classen).? But for others, both in biotechnology and IT, the effect should be minimal.? Admittedly, the mere changing of the test from one that was formerly more inclusive to one that narrows eligibility is potentially destabilizing?under the former machine-or-transformation test, ?administering? and ?determining? steps were generally transformative and therefore corresponded with patent eligibility.? But the key word is potentially, since the Prometheus patents already reflected an extreme stretching of section 101?s limits, and were also?as the Federal Circuit pointed out in its 2009 opinion?highly suspect under sections 102 and 103.

Tags: ACLU/Myriad Litigation, Bilski, Bilski v. Kappos, Classen, Classen Immunotherapies v. Biogen IDEC, diagnostic method patents, diagnostic patents, law of nature, method patents, Myriad, Myriad Genetics, Prometheus Laboratories, Prometheus v. Mayo, Supreme Court

Source: http://www.genomicslawreport.com/index.php/2012/03/21/prometheus-patents-struck-down-9-0-mayo-collaborative-services-v-prometheus-laboratories-inc-analysis/

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Tested Advice For Successful Private Growth Programs | All About ...

Many people try to find methods to improve on their own. They want to increase their prospect on lifestyle, increase their conduct, enhance their psychological state, and increase their behavior. The self-help ideas from the article listed below may help anyone who desires to try to enhance themselves as well as their lifestyle.

Dip Management

One fantastic tip regarding personal improvement is to produce a program and stick to it. Making a decide to have a purpose is fantastic, however it is only 50 % the fight. Recognize that setting up desired goals and producing plans is easy, executing them is definitely the hard portion.

Diploma Of Management

A wonderful way to improve one?s self esteem is always to prescribe for an exercise regimen. The positive power from exercising and also the fulfilling sense of attending a gym may help one?s self confidence greatly. Often all it will take to feel good is definitely an improved upon sensation of self worthy of.

Certificate 4 Frontline Management

A fantastic word of advice which can help you with the personal development targets, is to encompass your self with individuals who are positive and supportive. If you?re about unfavorable individuals at all times, it can be challenging that you should make any good modifications. Getting all around optimistic men and women may help a good deal.

Jot down your targets and blog post them somewhere obvious. Possessing a written listing provide you with some thing to pay attention to when taking care of your goals. It also could help you prioritize your targets to have them composed downwards, as possible then concentrate on the most significant things on your listing.

To reduce your levels of stress and disappointment above items you are not able to change, make an effort to cease stressing. Being concerned does tiny else apart from tax our minds, spirits, and physiques. In case you cannot regularly modify a scenario, you can find small really worth in worrying regarding this excessively. We have to discover how to accept the things we cannot transform!

As opposed to making it possible for tiny routines to snowball into a significant connection-tester, try and reassess your partner?s offensive or unwanted behavior differently. By way of example, tend not to resent your spouse due to the fact he or she does not clear toilets to the exacting specifications. Instead, concentrate on how good he helps to keep the lawn searching nice, or how thankful you might be that they even pitches in whatsoever!

Among the most difficult suggestions to swallow is to accept pin the blame on. Consider the obligation for anything that goes incorrect within your day time-to-day daily life. Don?t make lame excuses, just own the minute. It is you containing paved the best way to this time and it is essential to be in the driver?s seat, regardless of purpose. With this particular, you will get the respect of the close friends, household and peers and wide open the entrance to many tremendous personal growth.

An excellent self assist tip which will help you make positive changes to life is to get started on respiration appropriate. Plenty of people create the miscalculation of inhaling quick, quick breaths. Breathing like this may cause you anxious. Attempt to focus on consuming in greater breaths to become more relaxed.

Training

Training and knowledge are a good point, but never take too lightly the potency of measures. Some principles and guidelines could help you be more content when you really utilized them in your everyday life. Can you believe in assisting other folks? Volunteer to assist a charity as an alternative to simply referring to whatever we should do as a modern society.

Training is amongst the most significant areas of personal improvement. Regardless of what, a greater diploma cannot harm you with your hunt for personalized and expert advancement. Try to find programs that interest you, are aligned with your job goals, and therefore are cost-effective and accessible to you. This is actually the key to success.

Establishing after your goals and aspirations to become better particular person or even to achieve and overcome new stuff, you have to keep on being educated and maintain your knowledge base broadening. This can be achieved via tradition official training or non-conventional approaches. By inspiring your thoughts and the body, you can be 1 phase closer to being anyone you wish to be.

Anyone has concepts and beliefs, but if you would like stay by them smartly, you have to manage to explain and justify them. Probably many of these values can be a product of the education and therefore are really not letting you at all. Keep in mind your concepts and do the best to find explanations for them.

In regards to personal advancement you must consider each and every possibility to more your education and learning whether or not it is self research or official schooling. This is important since the broader spectrum of expertise you have, the better ability you have to earn revenue plus share the knowledge with others.

A important element of personal growth is schooling. Want that career you?ve generally desired? Chances are, you?re planning to require an schooling to do this. Look at community universites and colleges and determine the one that is best customized for the level you are looking for on the value it is possible to afford. Curently have a college degree? Think about looking at some better training or Master?s plans!

As mentioned higher than, lots of people make an effort to boost their selves constantly. People look for approaches to improve prospect, behaviour, practices, and mentality. When you keep to the self-help tips that are in the write-up previously mentioned, start to further improve on your own that will create an enjoyable existence.

Source: http://china-china.org/2012/03/tested-advice-for-successful-private-growth-programs/

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Who is internet business professional mike dillard? | SEO

An internet business expert will have the ideas that will work effectively sufficient to generate a great income. Mike Dillard is amongst the most popular specialists in this business sector; some have even referred to him as the biggest guru in the world of internet marketing. The Elevation Group is his most recent creation. The product is largely an investment portal that imparts training on how to use the internet as an effective tool to grow any business or to revive a dead or dying one.

Internet Business Expert Mike Dillard ? Success Story:

Internet Business Expert Mike Dillard?s story of accomplishment is almost unreal and can simply be compared to a Hollywood script. His story is a regular subject of argument amongst his numerous admirers. He started as a mere waiter and ended up a millionaire in just a year and a half. He vividly remembers a period when an empty stomach would be a typical companion of his. Today, not just is he a self-made success, he?s also one of the most desired advisers in the world of online marketing.

Internet Business Expert Mike Dillard ? Products and Services:

Magnetic sponsoring is really a common multilevel marketing product which concentrates on methods for attracting free leads. This product, like many others from Mike Dillard, became an instant hit right after it was launched. The majority of his goods are spoken of positively by all who?ve used them. This is also true for those young and upcoming entrepreneurs who don?t have much experience in the internet business industry. Mike Dillard, like a mentor, makes use of his products an internet-based courses introducing interested entrepreneurs to multilevel marketing and online business marketing techniques. These courses are not just intended for beginners, but they are also for the more experienced business owners like managers, pros, business owners and other executives.

The majority of his students find his business courses refreshing and engaging. There are some who think that his products and services are costly compared to others on the market. This is also true for his newest product, The Elevation Group. Nonetheless, the majority of his former students claim that expensive or not, Mike?s products are worth it.

Listed Below Are Some Of Mike Dillard?s Products and Services:

? Magnetic Sponsoring
? Building on a Budget
? Black Belt Recruiting
? MLM Traffic Formula 2
? What?s working Now
? PPC Domination
? Copywriters Guild

These products are in the form of courses, newsletters, videos, books and eBooks. Some of his videos are completely free of charge. The Elevation Group is a membership club wherein an individual pays a monthly or yearly membership fee.

Internet Business Expert Mike Dillard ? Companies:

Mike Dillard has 4 different companies that focus primarily in the internet marketing industry. All his companies are involved in the selling of his products and memberships. These companies are named here:

? Magnetic Sponsoring
? The Elevation Group
? Better Networker
? Digital Planner

One of the many benefits of joining Mike Dillard?s subscription sites is the fact that one receives latest information and suggestions from this internet business expert.

Internet Business Expert Mike Dillard is definitely worth looking into however his products and services are not free of charge. For FREE training on starting your own online business click marketing for beginners.

Tags: Internet, Ning

Source: http://www.seogate.net/marketing/who-internet-business-professional-mike-dillard.html

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Stocks to Watch ? Newcastle Investment Corp. (NCT) |

Stocks to Watch ? Newcastle Investment Corp. (NYSE: NCT)

Newcastle Investment Corp. (Newcastle) serves as a real estate related investment and finance company. It focuses on investing in and managing a portfolio of real estate securities, loans and other real estate related assets. It conducts its business through for segments:

• Investments financed with non-recourse collateralized debt obligations (CDOs)
• Investments financed with other non-recourse debts
• Investments financed with recourse debt, including Federal National Mortgage Association (FNMA)/ Federal Home Loan Mortgage Corporation (FHLMC) securities
• Unlevered investments.

Real Estate Securities

The Company is involved in underwriting, acquiring and managing of a portfolio of credit sensitive real estate securities such as commercial mortgage backed securities (CMBS), senior unsecured real estate investment trust (REIT) debt issued by property REITs, real estate related asset backed securities (ABS), including subprime securities, and FNMA/FHLMC securities.

Real Estate Related Loans

It acquires and loans to real estate owners, including B-notes, mezzanine loans, corporate bank loans, and whole loans.

Residential Mortgage Loans

It acquires residential mortgage loans such as those manufactured housing loans and subprime mortgage loans.

Operating Real Estate

The Company acquires and manages direct and indirect interests in operating real estate.

The Company is located in New York City. It owns and manages a diversified portfolio of debt mostly secured by commercial and residential real estate. It is managed by an affiliate of Fortress Investment Group LLC. Fortress is a premier investment and asset management firm.

The Company?s central business strategy is investing in a diverse portfolio of real estate securities and other real estate-related assets. Its investment philosophy is built around the principles of investing in a moderate amount of credit risk, adhering to strong investment and credit discipline and actively managing the portfolio to achieve its objectives.

INVEST

The Company?s investments involve commercial mortgage backed securities, senior unsecured debt issued by property real estate investment trusts, credit leased real estate, asset backed securities and mortgage loans.

MATCH FUND

Moreover, Newcastle continues to seek to match fund its assets with respect to interest rates and maturities in order to minimize the impact of interest rate fluctuations on earnings, and to reduce the risk of refinancing its liabilities prior to the maturities of its assets.

MANAGE ASSETS

It manages its credit exposure through portfolio diversification and ongoing asset surveillance and selection.

Newcastle Investment Corp. (NYSE: NCT) ?52 week:? 3.56 ? 6.90??? Mkt cap: 628.98M?? Shares: 105.18M

Tags: NCT, NCT quote, NCT stock, NCT stock quote, Newcastle Investment, Newcastle Investment Corp., Newcastle Investment Corporation, Stocks to watch

Source: http://www.buypennystocks.com/penny-stocks-blog/stocks-to-watch-newcastle-investment-corp-nct

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Tips And Techniques That Every Cook Needs To Know | Anyameten

Developing your culinary skills is simple, as long as you do your research. Feel free to experiment with food and recipes, and find out what you?re best at making. This information will allow you to become a better cook and give you new things a try. Follow these tips to improve your knowledge of food and your cooking skills.

If you are a lover of fish, consider heading out to a local river, stream, or lake and catch fresh fish for dinner. Of course, this depends on if you have the available time to do so. Removing bones and filleting the fish can be difficult but it?s worth the effort to enjoy such a fresh piece of fish.

Hot milk can transform your mashed potato recipe. Simply add this hot milk to your potatoes prior to mashing. Bypass the cold milk if you want mashed potatoes to be fluffy with a light texture. Boring, lumpy mashed potatoes are for the birds.

You should use two timers, one on a watch and one on the oven. If you have a watch timer on you, you will hear it anywhere in the house.

You can dry out your own tomatoes. Cut Romas tomatoes in lengthwise halves, or slice ripe regular tomatoes into half inch slices for drying. Place on a cooling rack, cut-side up and lightly salt them. Heat your oven to 190 degrees and put the cooling rack with the tomatoes directly onto a cookie sheet, baking for no more than ten hours. Put them in plastic bags for freezer storage. Alternatively, dried tomatoes can be packed in a jar filled with olive oil and fresh herbs. Tomatoes stored in this fashion will last for two weeks in the refrigerator.

Many popular veggies and herbs have a strong residual odor that can remain on cutting boards well after use. Label the ending of your chopping board by marking it with ink. This will help you to identify the different sides of the board.

Frozen corn is a healthy and economical staple food, but serving it too often can inspire family rebellion. Give it a twist to quell mutinous rumblings at the dinner table. For a new taste that both kids and adults are sure to enjoy, add coconut flakes to the corn for a dish that is Thai-inspired and surprisingly delicious.

Incorporate some insights from this article and see how the results are displayed in your cooking ability. Try any of the ideas that appeal to you at least one or two times. Practice them and perfect your cooking skills. If you?re serious in your efforts, you?ll become a more proficient cook in a matter of days.

If Do you want to know more cooking recipes & tips? Visit this website for information.

Source: http://anyameten.com/tips-and-techniques-that-every-cook-needs-to-know/?utm_source=rss&utm_medium=rss&utm_campaign=tips-and-techniques-that-every-cook-needs-to-know

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The GOP's tax cut trick

When Republicans have nothing else to attack, they call for a tax cut. And it works.

Republicans are desperate. They can?t attack Obama on jobs because the jobs picture is improving.

Skip to next paragraph Robert Reich

Robert is chancellor's professor of public policy at the University of California at Berkeley. He has served in three national administrations, most recently as secretary of labor under President Clinton. He has written 13 books, including 'The Work of Nations,' 'Locked in the Cabinet,' and his most recent book, 'Aftershock: The Next Economy and America's Future.' His 'Marketplace' commentaries can be found on publicradio.com and iTunes.

Recent posts

Their attack on the Administration?s rule requiring insurers to cover contraception has backfired, raising hackles even among many Republican women.

Their attack on Obama for raising gas prices has elicited scorn from economists of all persuasions who know oil prices are set in global markets and that demand in the United States has actually fallen.

Their presidential ambitions are being trampled in a furious fraternal war among Republican candidates.

Their Tea Party wing wants to reopen the budget deal forged with Democrats after Republicans got bloodied by threatening to block an increase in the debt limit.

So what are Republicans to do now? What they always do when they have nothing else to say.

Call for a tax cut, of course.

It doesn?t matter that their new ?tax reform? plan (leaked to the Wall Street Journal late Monday, to be released Tuesday morning) has as much chance of being enacted as Herman Cain has of being elected president.

It doesn?t matter than the plan doesn?t detail how they plan to pay for the tax cuts. Or whether an even bigger whack would have to be taken out of Medicare than Paul Ryan?s original voucher plan ? which would drowned many elderly under rising medical costs.

It doesn?t even matter that the plan would probably raise taxes on many lower-income Americans,

All that matters is the headlines.

?House Republican Budget to Propose Lower Income Tax Rates,? says Bloomberg Businessweek. ?Republican Budget Plan Seeks to Play Up Tax Reform,? says Reuters. ?GOP?s Budget Targets Taxes,? blares the Wall Street Journal.

Presto. Republicans have gotten what they wanted on the basis of saying absolutely nothing.

The Christian Science Monitor has assembled a diverse group of the best economy-related bloggers out there. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger, click here. This post originally ran on www.robertreich.org.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/Br6nNcbfphA/The-GOP-s-tax-cut-trick

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Best bets: 'Hunger Games' about to begin

Lionsgate

Jennifer Lawrence stars as Katniss Everdeen in "The Hunger Games."

By Gael Fashingbauer Cooper

The week ahead's a good one for entertainment. The most awaited movie of the year, "The Hunger Games," hits theaters, "Mad Men" returns to TV and a whole bunch of great movies come to DVD and Blu-ray. Among this and the NCAA tournament, there's a lot to feast your eyes upon.

Movies
"The Hunger Games" is part of an enormously popular book trilogy, like "Twilight," and like "Twilight,"?it features a young woman torn between two young men. But there the comparisons end. No vampires in "Hunger Games," and heroine Katniss Everdeen (Jennifer Lawrence)?doesn't depend on a man to save her -- she goes out and fights to survive all by herself. Warning: If you don't already have your tickets, you may not be able to see this one right away. Tickets went on sale Feb. 22, and early screenings sold out in many theaters weeks ago. (Opens March 23.)

TV
The sexy 1960s ad men and women of "Mad Men" are back for season five. Star John Slattery told TV Guide, "There are some surprises coming this season that are so out of control. I wish we had cameras in people's houses and could watch them go, 'No way!' as they watch the show." The magazine says the two-hour season premiere is "built around a memorable party" and calls it "a clever and often bitterly amusing piece of writing by creator Matthew Weiner." (Premieres March 25, 9 p.m., AMC.)

DVD and Blu-ray
It's time to play the music! It's time to light the lights! "The Muppets" bet it all on their 2011 comeback movie, and it seems to have worked -- the movie was critically acclaimed and names such as Kermit the Frog, Miss Piggy, Gonzo and Fozzie Bear are now?familiar to a new generation. And the classic "Man or Muppet?" won the Oscar for best song. Manly Muppets and Muppets of men (and women) will want to see this. (On DVD and Blu-ray March 20.)

?

Stieg Larsson's "Girl With the Dragon Tattoo" books have spawned not one but two separate movie series. The Swedish film trilogy was so acclaimed that many wondered why Hollywood even needed to make an American version. But the first?film in that series,?with Daniel Craig and Rooney Mara starring, earned raves. U.S.A.! U.S.A.!?(Out on DVD and Blu-ray March 20.)

"Hop" might make a fun Easter basket addition for the kids in your life. Animation and live-action blend in this entertaining offering, with Russell Brand offering the voice of a young rebellious Easter Bunny and Hugh Laurie as his dad, who dreams of passing his title down to Junior. Pick up the movie and nestle it right in there next to the chocolate bunny. (Out on DVD and Blu-ray March 20.)

"Tinker Tailor Soldier Spy" didn't earn all the headlines that "The Artist" did, but the film was nominated for three Oscars, including Gary Oldman as best actor. Many fans of John LeCarre's spy novels felt that his hero, George Smiley, could never be played better than Alec Guinness did in the 1979 miniseries, but then came Oldman. Peter Travers of Rolling Stone calls his performance "flawless in every detail." (Out on DVD and Blu-ray March 20.)

Related content:

Source: http://entertainment.msnbc.msn.com/_news/2012/03/14/10688421-best-bets-finally-time-to-start-the-hunger-games

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Air cooling Installment, The particular Expert Providers That can ...

The water system, heat, and air cooling firm can provide you with a wide selection of Air conditioning designs to select from at inexpensive price points. The greater reputable organizations will often have your widest selection of well-liked makes to choose from so you can get the precise style you would like. You?ll be able to talk to a Heating and air conditioning expert as well as focus on all of your air conditioning wants as well as choices once you phone to set up a meeting. 1000 payday loan

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The major problem along with installing a great AC program by yourself can be deciding the correct size that will meet the needs of your house. In the event you install an aura restorative that?s too large for your residence, it is going to awesome your home quickly; nonetheless, it will also utilize more power and not properly get rid of the moisture. This Hvac method can also get growing process fertility cycles. Therefore although technique will make your home much cooler in a much faster price, it is going to result in too much humidity to be left up that may eventually lead to fungus difficulties.

Posted on:
March 17, 2012

Source: http://yourpatientprivacy.com/air-cooling-installment-the-particular-expert-providers-that-can-make-your-house-secure/

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Marcel Hirscher wins World Cup overall title

Austrian Marcel Hirscher reacts in the finish area of the alpine ski, men's World Cup super-G race, in Schladming, Austria, Thursday, March 15, 2012. (AP Photo/Keystone, Jean-Christophe Bott)

Austrian Marcel Hirscher reacts in the finish area of the alpine ski, men's World Cup super-G race, in Schladming, Austria, Thursday, March 15, 2012. (AP Photo/Keystone, Jean-Christophe Bott)

SCHLADMING, Austria (AP) ? Marcel Hirscher of Austria has won the overall World Cup championship, overtaking Beat Feuz of Switzerland with a giant slalom victory.

Hirscher captured Saturday's final giant slalom of the season to take the discipline title and go to the top of the overall standings.

Hirscher holds a 25-point lead over Beat Feuz, a speed specialist who said he won't ski Sunday's slalom, the season's last race.

THIS IS A BREAKING NEWS UPDATE. Check back soon for further information. AP's earlier story is below.

SCHLADMING, Austria (AP) ? Marcel Hirscher won the World Cup giant slalom title Saturday after Ted Ligety of the United States skied off course in the opening run of the season-ending race.

Ligety, who won three GS titles in the past four seasons, trailed Hirscher by 92 points and, with a victory worth 100 points, had to win the race to stand a chance of overtaking the Austrian.

Ligety led by 0.43 seconds at the final intermediate time but skied off and had to hike back up the hill to complete his run, finishing 11.16 seconds off the lead.

"There was only one option today ? winning or going home," Ligety said. "I tried everything so I can't blame myself."

Ligety won two GS races and led the standings early in the season, but had since been playing catch-up with Hirscher. Ligety added a third victory last weekend in Kranjska Gora, Slovenia, to retain his slim chance.

"With the season he's had, he deserved to win the globe," the American said of Hirscher. "For me it was a good year, it's just that someone else was better."

Hirscher won three GS races and eight events in total this season and is also in contention for the overall and slalom titles, which will be decided Sunday.

"What happened to Ted could have happened to me as well," Hirscher said. "I have now reached my goal for the season ? to win a crystal globe. Let's see if I can take the next step as well."

Hirscher trails leader Beat Feuz of Switzerland by 75 points in the overall standings. Feuz was in 25th position after the opening run. Only the top 15 earn World Cup points.

Austria's Hannes Reichelt posted the fastest time of 1 minute, 10.99 seconds to lead Hirscher by 0.22 and Alexis Pinturault of France by 0.24.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-03-17-SKI-Men's-World-Cup/id-9c8bbefc0d21460ea14f8c44db8eded2

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