[unable to retrieve full-text content]Forum: Movies, TV, & Music
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posted by jeffnuttalx @ 3:09 PM
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LOS ANGELES (TheWrap.com) ? "American Idol" winner Scotty McCreery committed a lip synching foul during Thursday's Macy's Thanksgiving Day Parade.
The cherubic singer missed his cue to begin crooning his hit single "The Trouble With Girls" during the festivities. That left McCreery miming vocal work after the song had started to play over the loudspeakers.
Perhaps the reigning "Idol" victor isn't cut out for this whole live performing thing.
During this year's World Series, McCreery had to restart the National Anthem after his microphone malfunctioned. He then proceeded to flub the lyrics.
You can see the parade fiasco here: http://www.thewrap.com/media/column-post/scott-mccreerys-macys-day-parade-lip-synching-fiasco-video-33068
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posted by jeffnuttalx @ 11:41 PM
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LIMA, Peru (AP) ? Peru's biggest mining investment is under threat and government social welfare programs with it as highlands peasants step up protests against a gold-and-copper mine they fear could taint and diminish their water supply.
About 400 protesters tried to enter the mine's grounds Friday and some hurled rocks at police, who responded with tear gas and shotgun blasts, wounding one protester in the leg, Interior Minister Oscar Valdes told a Lima TV station.
Opposition to the $4.8 billion project, an extension of the Yanacocha open-pit gold mine that is Latin America's largest, poses the first major challenge to President Ollanta Humala's leadership.
He won office in June after promising the very people now mobilizing against Conga, whose 51 percent owner is Denver-based Newmont Mining Corp., that he would put clean water above mineral extraction.
He told the residents of the northern state of Cajamarca, one of Peru's most heavily mined, during a May campaign swing that he would ensure their water supply "because you don't drink gold."
"You don't eat gold."
But as protests began to rattle the Conga project last month, with heavy equipment vandalized, roads blocked and work temporarily halted, Humala was modifying the message.
The choice, he now said, need not be water or gold. Peruvians can have both.
After thousands joined protests in Cajamarca against Conga on Thursday, Humala told a gathering of peasant organizations in the capital of Lima: "You have my word. The state will guarantee water. All our children must have water."
Work at Conga was suspended for a third straight day Friday as protests continued, and Valdes said the wounded man was among two protesters arrested. Newmont spokesman Omar Jabara said one Conga worker's truck was badly damaged Friday in a hamlet on the mine's periphery.
Peru's Environment Ministry began last month to review the project ? "some critical aspects of it," said Fausto Roncal, the ministry official in charge of evaluating environmental impact studies. He said its report would soon be delivered to Peru's chief Cabinet minister.
But investigative journalist Gustavo Gorriti reported Friday night on the IDL-Reporteros website that the 11-page report was delivered Thursday and raises "serious environmental objections." He said it recommends a "detailed hydrological and hydrogeological analysis" of the impact of the mine's two pits on an aquifer not adequately studied by Yanacocha.
Neither Roncal nor other Environment Ministry officials could immediately be reached for comment.
Once a fiery leftist, Humala slid toward the center to win the presidency of a nation that earns 61 percent of export revenues from mining. A boom in metals prices has fueled 7 percent annual economic growth over the past decade, and Humala inherited a nation with more than $40 billion in mining investment lined up.
But little of the mining wealth has reached the highlands where most mines are located and where Humala won office promising pensions for the elderly poor, a higher minimum wage, more education and health spending, rural electrification and sanitation.
To help finance those programs, Humala got the mining industry to agree to a windfall tax that the government says will reap more than $1 billion a year.
Conga mining is scheduled to start in 2015 and is projected to yield 11.6 million ounces of gold ($20 billion at today's prices) and 3.1 billion pounds of copper ($10 billion at today's prices) over two decades.
If the project is scratched, investor confidence could sag and the underpinning of Humala's social agenda collapse.
"This is a trial balloon for the pact Humala's government made with the mining impresarios," said Julia Cuadros, executive director of Cooperaccion, a nonprofit organization that promotes sustainable development.
Yet local opposition to the project is stiff, and led by elected officials. Critics say an environmental impact study for Conga that was approved last year doesn't adequately address the potential downstream damage of gouging open pits into mountaintops in what is likely an important aquifer.
It "will eliminate the principal mountain lakes of the region, which are the last that remain that can supply urban expansion in the coming years" Cajamarca's regional president, Gregorio Santos, told The Associated Press.
Not just the 7,000 or so immediate inhabitants will be affected, he said, but tens of thousands in valleys below. At risk, Santos added, are "probable water supply sources for forestation and sustainable agriculture programs, and also for fish farming."
Four man-made reservoirs will replace the four small mountain lakes to be displaced by the 8-square-mile (2,000-hectare) project at the headwaters of two rivers. The biggest reservoir will be used to help extract metal from rock crushed and laced with cyanide before settling it on barriers to prevent ground contamination.
The other three, said Newmont's Jabara, will more than double stored water for surrounding communities.
"We're doing everything that we can to make sure this project is environmentally sound," Jabara said. That includes a willingness to modify the environmental impact. "At the end of the day a project can't be successful if it ends up adversely affecting water supplies."
But environmentalists say that's exactly what happened with the Yanacocha mine, which began operating in 1993 and produced 3 million ounces of gold in its best year.
Peru's relatively lax clean-water standards permitted it to contaminate waterways, they say, while the regulatory process is biased in favor of miners because the Mining Ministry has the last word on environmental impact studies for mining projects.
"That doesn't happen in Chile, Colombia or Ecuador," said Manuel Glave, a respected Lima economist.
Peru currently has more than 60 disputes over the alleged detrimental impact of mining on water supplies, according to the national ombudsman's office.
The rancor has put an end to some projects.
Former President Alan Garcia's government, which approved Conga and was bullish on mining, nevertheless halted the Tia Maria project of Mexican-owned Southern Copper Corp. in April after three protesters died in clashes with police.
But Garcia's government also often sought the arrest of anti-mining and other protest leaders.
Humala may be similarly inclined. A top lawyer in the Interior Ministry, Julio Talledo, told the AP it has asked prosecutors to file criminal charges against Gregorio Santos and four local leaders who have led protests against Conga. The charges include "hindering the functioning of public services" and carry prison terms of at least two years. Prosecutors have yet to act on them.
Conga's credibility issues owe to past behavior of the Yanacocha consortium, which includes the Peruvian company Buenaventura Mining Co. and the International Finance Corporation, with a 5 percent stake, according to analysts.
In 2000, hundreds were sickened when a Yanacocha contractor spilled 335 pounds (150 kilograms) of mercury, a byproduct of the mine.
The consortium later provoked protests with exploratory drilling at the nearby Cerro Quilish. It shelved that project after complaints it would directly affect the water of the regional capital of 350,000 people.
More broadly, resistance to mining may owe more to the fact that it employs relatively few Peruvians, just 126,000 out of a population of more than 29 million.
Conga has 6,800 workers, mostly locals who live in wind-swept mountains dominated by subsistence farmers where running water, electricity, decent schools and health care have been in short supply.
The Yanacocha consortium is sponsoring projects in the mining zone that it says will address those deficiencies.
Yanachocha paid a total of $292 million in income taxes and royalties last year and made voluntary contributions of $29 million ? not including social investments, Jabara said.
___
Associated Press writers Franklin Briceno and Martin Villena contributed to this report.
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posted by jeffnuttalx @ 8:12 AM
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ScienceDaily (Nov. 23, 2011) ? Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes.
The study, which was published in the November 25, 2011 print edition of The Journal of Biological Chemistry, focused on the melanocortin-3 receptor (MC3R), which normally responds to signals of nutrient intake.
"What we discovered was quite a surprise," said Scripps Research Associate Professor Andrew Butler, who led the study. "We thought that the actions of the receptor expressed in the brain would be critical for metabolic homeostasis. However, what we found is that actions of the receptor expressed outside the brain appear to be equally important."
The existence of drug targets in areas outside of the central nervous system (the body's "periphery") might help in the effort to develop drugs that influence metabolism without major side effects, Butler said.
The findings were made possible by the team's development of a new transgenic animal model, where expression of the MC3R gene can be selectively "switched on" in different cell types.
In the study, the suppression of MC3R expression in the brain and peripheral tissues had a marked impact on metabolic homeostasis (equilibrium). Interestingly, mice expressing the MC3R gene in the brain only displayed an obese phenotype (physical appearance) similar to those where all types of expression was suppressed, indicating that actions of this receptor in the brain are not sufficient to protect against weight gain. The finding that loss of MC3R activity in the periphery impairs metabolic homeostasis is startling, Butler said, and point to a distinct role for MC3R signaling in the peripheral tissues. However, how the actions of these receptors impacts on obesity remains to be determined.
"It's clear that these peripheral receptors are important and the new mouse model will let us explore that potential," Butler said.
The study was supported by National Institutes of Health and the Pennington Biomedical Research Foundation.
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Source: http://www.sciencedaily.com/releases/2011/11/111123190400.htm
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posted by jeffnuttalx @ 4:26 PM
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updated 9:04 a.m. ET Nov. 25, 2011
APIA, Samoa - Two days after winning for the first time in its history, American Samoa's national soccer team stretched its unbeaten run to two games.
After Tuesday's 2-1 win over Tonga, the team earned a 1-1 draw with the Cook Islands on Thursday. Another win against rival Samoa on Saturday will put the U.S. protectorate into the second round of World Cup qualifying in the Oceania region.
American Samoa coach Thomas Rongen, a former Ajax player and veteran MLS coach, says "we made it very hard for ourselves again but we got the result we needed to make the game against Samoa, who I consider the best team here, a meaningful contest."
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsAFP - Getty ImagesRoundup: Arsenal clinched a place in the second round of the Champions League on Wednesday night with a 2-1 win over Borussia Dortmund, but the Gunners could find themselves the only English club in the knockout stage.
For the first time in decades, football in Libya is just about, well, football.
Source: http://nbcsports.msnbc.com/id/45435383/ns/sports-soccer/
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posted by jeffnuttalx @ 12:48 AM
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How many of you know that Romneys 20 year job at Bain Capital was as a Wall Street Hedge Fund Manager? All occupy issues aside (what ever they are?) Wall Street is not Capitalism. Its Banks. Socialist minded Investment Bankers. Isnt it bad enough that Wall Street accepted Obama as one of them - a Socialist - and financed his campaign? Do we really want a Wall Street Guy as President? ...... SAY "NO" TO ROMNEY
He looks Presidential. He talks Presidential. He has an inside track to the Wall Street Bankers who got all the Stimulus money.... He is a ringer for the same team that funded Obama. I bet he gets the Rep Nomination then throws the fight.... Oh here's one more... I heard Romneys Father was a Union Rep... another Socialist Group that funded Obama and Romney has inroads there too. I say he is on the same team as Obama and I dont want him.
Simply put. A lot of his Bain deals were co-financed by Goldman Sachs, who happen to be his largest campaign contributors currently. A Wall Street guy for sure. He is not going to be good for the country.
It is the conflicted interests between Wall Street and the White House that bothers me. Absolute power corrupts absolutely
Pres. Reagan said the first loss of freedom will come in the form of Socialized Medicine. Its really neat-o how both Romney and Obama made that their main priorities.
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posted by jeffnuttalx @ 9:15 AM
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Charles Rex Arbogast / AP
Very few shoppers set a strict holiday budget, according to a new survey.
By Allison Linn
Given the state of the economy, it comes as no surprise that many Americans are worried about how they?ll be able to pay for all their holiday expenses.
The trouble is, most of us don?t seem to be doing much to plan for it.
A new survey from the National Endowment for Financial Education finds that just 31 percent of consumers plan to set a budget this holiday season. That?s only slightly more than last year, when 27 percent said they were making a budget.
The vast majority said they weren?t going to set a holiday spending budget. Still, only 10 percent said they often spend more than they want to. That?s about the same as last year.
The wealthier the household, the less likely they were to set a budget.
Half of the people NEFE surveyed said they were more worried about being able to afford holiday expenses than they were five years ago. Nearly 4 in 10 are just as concerned about holiday spending as they were five years ago.
Harris Interactive conducted the survey of about 2,800 adults earlier this month on NEFE?s behalf.
Related:
Shop smart and save money this holiday season
'Christmas creep' annoys, but seems to work
Do you set a budget for holiday spending?
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posted by jeffnuttalx @ 5:31 PM
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Having successfully created and launched a business where robots dart through distribution centers securing e-commerce products for delivery, Kiva Systems founder, Mick Mountz reflects on growing his company to 250 employees in just under a decade - and the company culture that organically formed alongside it. Mountz tells Founder Stories host Chris Dixon that Kiva Systems didn't define its culture until "about five years" into operations. "We took this kind of latent approach, which is go fast, have fun, build, be competitive, be successful, and then people would come in and say jeez you got a great culture here and we said oh, that is interesting, what is it?"Source: http://feedproxy.google.com/~r/Techcrunch/~3/EOFSwZe6NEA/
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posted by jeffnuttalx @ 1:55 AM
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TRIPOLI (Reuters) ? The International Criminal Court's chief prosecutor conceded Tuesday that the captured son of Muammar Gaddafi may be tried in Libya rather than in The Hague, meaning he faces the death penalty if convicted.
While ICC prosecutor Luis Moreno-Ocampo met officials in Tripoli, the National Transitional Council (NTC) prepared to unveil a new government line-up that would have to reconcile regional and ideological interests whose rivalry threatens to upset the country's fragile stability.
Three months after Muammar Gaddafi's control over Libya was ended and a month after the former leader was killed on a roadside near his hometown, Libya is struggling to build new institutions out of the wreckage of his 42-year rule.
The Hague-based ICC has indicted Gaddafi's son, Saif al-Islam, for crimes against humanity. But Moreno-Ocampo said Saif al-Islam, who was captured Saturday, could be tried inside Libya as long as the trial complies with ICC standards.
"Saif is captured so we are here to ensure cooperation. Now in May, we requested an arrest warrant because Libyans could not do justice in Libya. Now as Libyans are decided to do justice, they could do justice and we'll help them to do it, so that is the system," he told reporters on his arrival in Tripoli.
"Our International Criminal Court acts when the national system cannot act. They have decided to do it and that is why we are here to learn and to understand what they are doing and to cooperate."
Libyan officials have promised a fair trial but the country still has the death penalty on its books, whereas the severest punishment the ICC can impose is life imprisonment.
"The law says the primacy is for the national system. If they prosecute the case here, we will discuss with them how to inform the judges and they can do it. But our judges have to be involved," said Moreno-Ocampo.
Saif al-Islam was captured in an ambush deep in the Sahara desert and is now being held in the town of Zintan, in the Western Mountains region where his captors are based.
An NTC spokesman in Tripoli had described the arrest of Saif al-Islam, the last of Muammar Gaddafi's offspring whose whereabouts had been unaccounted for, as "the last chapter in the Libyan drama."
An official in Zintan told Reuters steps were already underway for Saif al-Islam's prosecution. "A Libyan prosecutor met with Saif (on Monday) to conduct a preliminary investigation," said Ahmed Ammar.
REGIONAL RIVALRIES
His arrest, while celebrated by people shooting their weapons into the air around the country, has exposed the tensions between regional clans.
The fighters from Zintan who seized him Saif al-Islam flew him in a cargo plane to their hometown instead of taking him to Tripoli. They are holding him in Zintan until the central government is formed.
The NTC said prime minister designate Abdurrahim El-Keib would be announcing the cabinet line-up at about 5 pm (1500 GMT) Tuesday.
Forming the government -- which will run the country until elections are held -- is tricky because it could inflame regional rivalries if any of the competing groups feel their candidates have been excluded.
Earlier Tuesday, an NTC source told Reuters the council had decided to appoint as the new defense minister the commander from Zintan whose forces captured Saif al-Islam.
Osama Al-Juwali, head of the military council in Zintan, was given the defense job as part of a cabinet line-up in which secularist liberals were dominant and which had no key roles for the Islamists who have been making a bid for power since Gaddafi's fall.
In other appointments, Libya's deputy envoy to the United Nations was named as foreign minister, an oil company executive was made oil minister and the finance minister in the outgoing government was re-appointed, the source said.
However, in an indication of the tensions around the cabinet composition, the source later said some NTC members, after agreeing the appointments, had re-opened the discussions.
"There are some people who do not accept some of the names," said the source, who spoke on condition of anonymity. It was not clear which posts were the subject of debate.
MOUNTAIN POWERBASE
Juwali is a former officer in the Libyan military whose forces from Zintan played a crucial role in the offensive on Tripoli which ended Gaddafi's rule in August. He had not previously been seen as a contender for the defense job.
But he appeared to have staked a claim to the post after forces under his command captured Saif al-Islam, who had been on the run for months.
The defense minister's role had been coveted by Islamists, who assumed powerful roles in the chaos following Gaddafi's fall after being persecuted for years.
The source said the NTC had agreed to appoint Ibrahim Dabbashi, the deputy U.N. envoy, as foreign minister. He came to prominence soon after Libya's revolt erupted in February, when he broke with Gaddafi and sided with the rebellion.
Ali Tarhouni, an academic in the United States who returned from exile to run the oil and finance portfolio in the anti-Gaddafi rebellion, was made finance minister, the source said, while Hassan Ziglam, an executive in a Libyan oil company, was given the oil minister's portfolio.
Many of the most powerful players in post-Gaddafi Libya have opted to stay out of the government, preferring instead to focus on winning office when elections are held. These should take place within eight months, according to a timetable the NTC has set itself.
(Additional reporting by Marie-Louise Gumuchian, Hisham El Dani in Tripoli, Oliver Holmes and Taha Zargoun in Zintan; Writing by Christian Lowe; Editing by David Stamp)
Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20111122/wl_nm/us_libya
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posted by jeffnuttalx @ 10:20 AM
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Fracking is quickly becoming a slang term many in the shale boom region are learning. The debate among some environmentalists, natural gas companies and communities in dire need of jobs centers primarily on the fluids used during the hydraulic fracturing process and regulatory monitoring. Fracturing fluid is pumped from a horizontal gas well through a thick steel pipe to fracture shale deposits releasing natural gas deposits.
A U.S. House, Energy and Commerce Committee report released earlier this year identifies 2,500 types of fracturing fluids commonly used during the shale drilling process. Here are some facts and figures about hydraulic fracturing and shale drilling regulations.
750: Hydraulic fracturing products that contain chemicals and other nonorganic components of the 2,500 noted in the congressional report.
270: Hydraulic fracturing liquid ingredients not disclosed by the manufacturing company due to trade secret laws.
2,500: Feet shale drilling will set back from private and public water sources if recently introduced Pennsylvania legislation gains approval. Current rules requires drilling occur at least 1,000 feet from water sources.
342: Companies that include methanol in fracking liquids.
42: Shale drilling companies that use hydrocholic acid in hydraulic fracturing mixtures.
1,500: Feet around pumping wells the EnerVest natural gas drilling company tests for water contamination.
274: Currently used fracking liquid mixtures which utilize isopropyl alcohol.
207: Natural gas drilling liquid mixtures which include sand or cystaline silica.
3,800: Natural gas wells operating in Pennsylvania since the shale boom began in 2005.
126: Fracturing liquid recipes that include ethylene glycol monobutyl.
89: Hydro-treated light petroleum distilates that appear in fracking fluid mixtures.
80: Natural gas drilling companies that use sodium hydroxide when fracturing shale deposits.
11: Times a natural gas company was able to withhold at least one ingredient in a hydraulic fracturing liquid mixture during the government study due to the proprietary nature of the compound.
51: Times diesel fuel is listed in hydraulic fracturing liquid mixtures in the congressional study.
44: Companies that use napthalene when drilling for natural gas.
42: Times xylene is included in fracking liquid mixtures.
29: Times toluene is used in fracking brine when drilling for shale deposits.
28: Natural gas drilling companies that list ethylbenzene as an ingredient in hydraulic fracturing liquids.
14: Times diethanolamine appears in fracking mixture recipes.
9: Times nitrilotriacetic acid, benzyl chloride, sulfuric acid, cumene and tholourea are included in fracturing liquid products.
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posted by jeffnuttalx @ 7:46 AM
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Rich Schultz / AP
The Campbells with their son, Adolf Hitler.
A New Jersey couple who lost custody of their first three kids after giving them Nazi-inspired names has been denied the right to take home their fourth child, a newborn boy they named Hons.
Heath and Deborah Campbell's other children - Adolf Hitler Campbell, JoyceLynn Aryan Nation Campbell and Honszlynn Hinler Jeannie Campbell - are in foster care. On Monday, the Campbells went to family court in their hometown of?Flemington, N.J,. in a bid to regain custody of Hons, who they say was taken from them by state child welfare officials hours after Deborah gave birth on Thursday, reported myfoxphilly.com.
Hons is still in the hospital, but the couple has been barred from seeing the baby, they told FOX. Heath Campbell said police came into the nursery and took Hons without a court order.
?They kidnapped my kid,? Campbell said. ?I?ve been sleeping with his little blanket from the hospital.?
The state took custody of the couple?s other children nearly two years ago, saying there were in danger because of previous violence in the Campbell home, The Associated Press has reported. The Campbells have been fighting to get their children back ever since, claiming the violence charges are fabricated. It wasn't clear whether the latest court hearing involved all of the children or just the newborn.
The Campbells came into the spotlight in 2009 when a supermarket refused to ice a birthday cake for their now 4-year-old son Adolf Hitler.?
Heath Campbell defended the children's names and told myfoxphilly.com on Monday that his reverend approved of him naming his new son Hons.
The Campbells have denied that they are neo-Nazis.
Read more on myfoxphilly.com.
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posted by jeffnuttalx @ 6:45 PM
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November 21, 2011 |??2
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About the Author: Bora Zivkovic is the Blog Editor at Scientific American, chronobiologist, biology teacher, organizer of ScienceOnline conferences and editor of Open Laboratory anthologies of best science writing on the Web. Follow on Twitter @boraz.More??
The views expressed are those of the author and are not necessarily those of Scientific American.
Source: http://rss.sciam.com/click.phdo?i=fbcf6df4c44965a50ca72f46b0bf670d
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posted by jeffnuttalx @ 4:16 PM
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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/164284684?client_source=feed&format=rss
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posted by jeffnuttalx @ 3:20 AM
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Having successfully created and launched a business where robots dart through distribution centers securing e-commerce products for delivery, Kiva Systems founder, Mick Mountz reflects on growing his company to 250 employees in just under a decade - and the company culture that organically formed alongside it. Mountz tells Founder Stories host Chris Dixon that Kiva Systems didn't define its culture until "about five years" into operations. "We took this kind of latent approach, which is go fast, have fun, build, be competitive, be successful, and then people would come in and say jeez you got a great culture here and we said oh, that is interesting, what is it?"Source: http://feedproxy.google.com/~r/Techcrunch/~3/EOFSwZe6NEA/
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posted by jeffnuttalx @ 12:49 AM
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Enlarge Robert F. Bukaty/AP A technician holds a laboratory mouse at the Jackson Laboratory in Bar Harbor, Maine. The lab ships more than two million mice a year to qualified researchers.
Robert F. Bukaty/APA technician holds a laboratory mouse at the Jackson Laboratory in Bar Harbor, Maine. The lab ships more than two million mice a year to qualified researchers.
The lab mouse is the most ubiquitous animal in biomedical research, but that doesn't mean it's always the best subject for researching disease.
In a series of articles for Slate magazine, Daniel Engber looked into why the mouse is such a mainstay of science ? and whether that's a good thing.
"All of this is about standardization," Engber tells weekends on All Things Considered guest host Laura Sullivan. "It's easier for scientists ? and it's cheaper ? if everyone's using the same animal."
A 2008 study by the European Union found that mice accounted for about 59 percent of animals used for lab experiments. In fact, the number of mice studies has quadrupled since 1965, according to the National Library of Medicine databases. In contrast, studies on dogs and cats, rabbits, guinea pigs, zebra fish, fruit flies and other animals have remained about the same.
There's a monoculture in biomedical research that revolves around mice testing, Engber explains. Mice are easy to get and easy to maintain. It's easier to acquire grant money for studies on mice than for other, more complicated animals. But that doesn't mean they're the right animal for the job.
Take tuberculosis, for example. Mice have been used almost exclusively in tuberculosis research for the last 30 or 40 years, Engber says, but because the human respiratory system is structured differently, mice and humans actually get different types of tuberculosis.
"Any animal model you use for disease is going to be similar to the human version of disease in some ways and different in other ways," he says. "If all of your experiments are done on the same animal, those differences are just going to keep coming up again and again and again. It's self-limiting."
Not only that, lab mice are sedentary and overweight compared to their wild counterparts. Engber says that can skew the baseline of any study requiring a healthy mouse for a constant.
So why not switch to another animal?
Mice remain the number one subjects because so many tools used in research and genetic engineering are built around the mouse, Engber says. For many scientists, switching would be expensive and abrupt ? almost like switching a language.
"In science, in bio-medicine, people talk about being, you know, 'I'm a mouse person. I'm a monkey person'," Engber says. "At conferences, the mouse people will sort of cluster around posters of mouse studies and monkey people will cluster around posters of monkey studies."
But with the modern lab mouse almost exhaustively studied, he suggests, diversification could lead to new scientific discoveries.
"Let's invest more money into at least developing the science of the naked mole rat, the marmoset, the python ? whatever. Some other animals that might have some other secrets to share about the nature of disease."
Source: http://www.npr.org/2011/11/19/142517645/perhaps-scientists-like-lab-mice-too-much?ft=1&f=1007
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posted by jeffnuttalx @ 11:53 AM
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LOS ANGELES (TheWrap.com) ? The Bluths are back.
For the first time since "Arrested Development" was canceled ii 2006, the dysfunctional and ethically challenged Southern California clan will return for all new episodes.
The show will be available exclusively to Netflix members beginning in 2013.
Terms of the deal were not disclosed.
Twentieth Century Fox Television and Imagine Television will produce the show.
The move is a huge boost to Netflix, which has been trying to establish a presence in the original content world. Last summer, the subscription service beat out the likes of HBO for the rights to the David Fincher and Kevin Spacey political series "House of Cards."
The cult hit aired for three seasons, 2003-2006, on Fox and won an Emmy for "Best Comedy." Showtime had reportedly been pursuing rights to air the show, as well.
In a releasing announcing the shows, Netflix made no mention about whether the entire cast, which includes Jason Bateman, Will Arnett, David Cross, and Michael Cera, will return for another round. However, Cross, Bateman and Arnett have spoken enthusiastically about a reunion.
"Netflix's bold entrance into original programing presents an exciting new opportunity for our two companies" Peter Levinsohn, Fox Filmed Entertainment's President of New Media & Digital Distribution, said in a statement. "Bringing a classic show back to production on new episodes exclusively for Netflix customers is a game changer, and illustrates the incredible potential the new digital landscape affords great content providers like Twentieth Century Fox Television and Imagine."
News that "Arrested Development" was getting a revival, broke after co-creator and executive producer Mitch Hurwitz announced at a New Yorker Festival reunion in October that he planned to bring back the show for an abbreviated season to lead into a long-awaited "Arrested Development" movie.
At the time, Hurwitz said that the show would catch up viewers on what the members of the deeply disturbed Bluth family have done since the series ended, and would run for nine to ten episodes.
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At least two rocket-propelled grenades hit a building belonging to the ruling Baath party in Damascus on Sunday, residents said, in the first insurgent attack reported inside the Syrian capital since an eight-month uprising began against President Bashar Assad.
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"Security police blocked off the square where the Baath's Damascus branch is located. But I saw smoke rising from the building and fire trucks around it," one witness, who declined to be named, told Reuters.
"The attack was just before dawn and the building was mostly empty. It seems to have been intended as a message to the regime," he said.
The Syrian Free Army, comprised of army defectors and based in neighboring Turkey, claimed responsibility for the attack, just as Assad vowed in an interview to crush the insurgency and pursue a crackdown on protests demanding his removal that has killed 3,500 people, by a U.N. count.
The attack could not be independently confirmed. Syrian authorities have barred most independent journalists from entering the country.
Story: Syria's Assad vows to continue crackdown despite Arab League pressureThe Local Coordination Committees activist network and several residents reported several explosions in the district of Mazraa in the heart of the Syrian capital.
The LCC said in a statement that the building had been hit at daybreak Sunday by several rocket-propelled grenades and that two fire brigades headed toward the area amid heavy security presence.
However, eyewitnesses said the building looked intact Sunday.
Residents in the Syrian capital said they heard two loud explosions but could not confirm whether the building had been hit.
"I woke up to the sound of two loud thuds," said a resident of the area who asked that he remain anonymous for fear of reprisals.
Story: Russia warns Syria is close to 'real civil war'Damascus-based journalist Thabet Salem, who lives about a kilometer away from the Baath party building and heard the explosions, said if the reports are confirmed, it would signal a new phase in the Syrian uprising.
"It would be an escalation that gives a new dimension to the whole situation," he said.
Syria's uprising against Assad has grown more violent and militarized in recent weeks, as frustrated protesters see the limits of peaceful action.
Why Syria?s revolution needs a BenghaziArmy dissidents who sided with the protests have also grown more bold, fighting back against regime forces and even assaulting military bases.
The so called Free Syrian Army group of dissident soldiers this week staged their boldest operation yet, attacking a military intelligence building in a Damascus suburb .
Assad, who inherited power from his father in 2000, is a member of the Alawite minority community, an offshoot of Shiite Islam that dominates the state, the army and security apparatus in the majority Sunni Muslim country of 20 million.
The Syrian Free Army said in a statement Sunday's attack came in response to the authorities' refusal to release tens of thousands of political prisoners and pull the military out of restive cities in accordance with a plan agreed between the Arab League and Damascus.
An Arab League deadline for Syria to end its repression of the unrest passed with no sign of violence abating.
Activists in the central city of Homs said the body of Farzat Jarban, an activist who had been filming and broadcasting pro-democracy demonstrations in the city, was found dumped near a private hospital on Saturday with two bullet wounds.
"Security police are no longer just shooting protesters, they are targeting activists when they least suspect it, such as when they take their children to school. Sometimes they don't shoot to kill but to neutralize," said a doctor from Homs who has fled to Jordan.
"I treated an activist recently...They shot him in the thigh and by the time his family got him to me gangrene had spread and his leg needed to be amputated," he said.
'Terrorists'
Authorities blame the violence on foreign-backed armed groups which it says have killed some 1,100 soldiers and police.
Tanks and troops deployed in Homs after large anti-Assad protests six months ago. The authorities say they have since arrested dozens of "terrorists" in the city who have been killing civilians and planting bombs in public places.
The Syrian Observatory for Human Rights said security forces killed 16 civilians in raids and in shootings on protesters on Saturday, including two at a funeral in Kfar Tkharim in the northwestern Idlib province on the border with Turkey.
The Arab League had set a Saturday deadline for Syria to comply with a peace plan which would entail a military pullout from around restive areas, and threatened sanctions if Assad failed to end the violence.
The league, a group of Arab states, suspended Syria's membership in a surprise move last week.
Video: Crisis accelerates in Syria (on this page)Non-Arab Turkey, once an ally of Assad's, is also taking an increasingly tough attitude to Damascus.
Turkish newspapers said on Saturday Ankara had contingency plans to create no-fly or buffer zones to protect civilians in neighbouring Syria if the bloodshed worsens.
Dissident colonel Riad al-Asaad, organising defectors in Syria from his new base in southern Turkey, said in a television interview with Al Jazeera on Saturday that no foreign military intervention was needed other than providing a no-fly zone and weapons supplies.
He said more deserters would swell his Free Syrian Army's ranks if there were protected zones to which they could flee: "Soldiers and officers in the army are waiting for the right opportunity."
Story: Assad's forces shell Syria villages for hoursThe dissident colonel denied government allegations that neighbouring states were allowing arms smuggling into Syria. He said "not a single bullet" had been smuggled from abroad.
Weapons were brought by defectors, obtained in raids on the regular army or bought from arms dealers inside Syria, he said.
The Associated Press and Reuters contributed to this report.
Source: http://www.msnbc.msn.com/id/45374621/ns/world_news-mideast_n_africa/
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Justin Bieber and Selena Gomez aren't letting that pesky paternity scandal come between them.
A source tells Us Weekly the 17-year-old singer "was in great spirits when he came for a couple hours to rehearse" for the American Music Awards on Saturday.
PHOTOS:Justin and Selena's beach PDA
In the front row? The singer's 19-year-old girlfriend, who stood by him when Mariah Yeater first accused him of fathering a baby boy.
PHOTOS: Bieber's biggest Beliebers!
"At one point Justin even sang 'I Feel Good' a la James Brown!" the source adds. "They were totally adorable. They were snuggling in between takes, and he was serenading her! They look as in love as ever."
PHOTOS: Selena's best red carpet looks ever!
Bieber -- who still plans to take a DNA test despite Yeater dropping her lawsuit -- is scheduled to perform a song from his new holiday CD, Under the Mistletoe. Gomez is slated to present at the awards show, which will feature performances by Jennifer Lopez and Nicki Minaj.
The American Music Awards airs live on Sunday at 8 p.m. EST.
Get more Us! Follow us on Twitter, Friend us on Facebook, Subscribe to Us Weekly
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BERLIN (Reuters) ? The leaders of Germany and Britain sent out conflicting signals on Friday about how to solve the euro zone's debt crisis and admitted they had failed to narrow differences over the introduction of a financial transaction tax in Europe.
At a news conference in Berlin, British Prime Minister David Cameron and German Chancellor Angela Merkel tried to paper over divergent views on European policy that have sparked a war of words between politicians and media in both countries.
But they could not mask differences over how the single currency bloc's debt crisis should be handled, with Cameron calling for "decisive action" to stabilize the euro zone and Merkel making clear she favored a "step-by-step" approach.
"My German isn't that good, I think a bazooka is a superwaffe, am I right?" Cameron said in response to a question about his call for euro zone policymakers to use a "big bazooka" approach to the crisis.
"The chancellor and I would agree that whatever you call this we need to take decisive action to help stabilize the euro zone," he said, citing the need for strong action on Greece, a rescue fund with "power and punch" and a recapitalisation of European banks.
Merkel struck a more cautious note. She has come under pressure to support bolder crisis-fighting steps from the European Central Bank (ECB), such as using it as a lender of last resort for the bloc or backstop for the bloc's bailout fund, the so-called European Financial Stability Facility (EFSF).
So far she has resisted, backing the argument of the German Bundesbank that this would violate the ECB's inflation-focused policy mandate. She is focusing on changes to the EU's Lisbon Treaty to force other euro members to adopt German budget discipline.
"The British demand that we use a large amount of firepower to win back credibility for the euro zone is right. But we have to take care that we don't pretend to have powers we don't have. Because the markets will figure out very quickly that this won't work."
SPEAKING GERMAN
Asked about Germany's push for the introduction of a financial transaction tax in Europe, Merkel admitted the two leaders "did not make any progress".
"Naturally there are differences. But Europe can only prevail if all the strong countries of the European continent are represented and if we have a bit of tolerance for the different views," Merkel said.
At a meeting of Merkel's Christian Democrats (CDU) earlier this week, the parliamentary leader from her party accused Britain of "only defending its own interests" and announced triumphantly that "Europe is speaking German all of a sudden", a reference to widespread acceptance of German fiscal rigor across the bloc.
The comments sparked a strong reaction in the British press with the Daily Mail saying: "We no longer need to fear the jackboot but we have a great deal to fear from German bossy boots."
Germany's top-selling Bild newspaper retaliated, asking on the morning of Cameron's visit: "What is England still doing in the EU?"
(Reporting by Stephen Brown and Andreas Rinke; Writing by Noah Barkin; Editing by Jon Hemming)
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Michael Nagle / Getty Images file
Shoppers look for bargains at Toys "R" Us last year. The big-box chain is opening at 9 p.m. on Thanksgiving this year.
By Marisa Taylor
Call it Black Friday fatigue.
With stores racing to open ever earlier on Thanksgiving (Wal-Mart?s doors will open at 10 p.m.!), a backlash is growing, with some retailers and analysts questioning the madness.
?The lunacy of opening at 12 midnight or even earlier on Thanksgiving evening shows that this whole Black Friday thing has run out of legs,? said IDC Retail Insights program director Greg Girard. ?Black Friday is a race to the bottom, and it?s just become another ad avenue.?
Other analysts think this year's extended hours are meant to distract shoppers from a lack of exciting inventory.
?If you build it, they will come,? said NPD Group chief industry analyst Marshal Cohen, ?but they won?t come in the dead of night. To me, you?re not going to sell more product just because you?re open more hours. It?s more of a smoke screen than it is a solution to the issue.?
This year, some stores are choosing not to take extreme measures to lure in bargain-hungry customers as they kick off a season that is expected to bring in about $465.6 billion in sales, a modest 2.8 percent increase over last year.
Sears, for one, has decided to pass on the trend for midnight openings set by big-box retailers including Best Buy, Kohls and Target. Toys 'R' Us is opening at 9 p.m. Thanksgiving night, an hour ahead of Wal-Mart.
Last year, Sears chose to keep its doors open on Thanksgiving from 7 a.m. until noon, with the idea that shoppers would come in early to rack up a few deals and then head home to their families for a midday meal.
But while the company did have good numbers that day, ?The customer feedback was very clear,? said Sears spokesman Tom Aiello. ?The customers liked the deals, but they didn?t like the idea of Thanksgiving shorted as a holiday.?
So the chain will revert to its original plan to open at 4 a.m. on Friday. ?I think there?s a group of customers that don?t aspire to get up in the middle of the night,? Aiello said.
Retail chain JC Penneyalso decided to stick with a 4 a.m. opening time this year so employees can spend Thanksgiving with friends and family, according to a company spokesman.
Employees at Target and Best Buy have launched petition drives on the website change.org protesting the early openings. ?A midnight opening robs the hourly and in-store salary workers of time off with their families on Thanksgiving Day,? wrote petition creator Anthony Hardwick, who identifies himself as a Target employee.
Some local retailers are still undecided on their Black Friday hours and will make last-minute decisions, according to Cohen.
Others are resisting the bonanza that is Black Friday altogether?or at least, they engage in more subtlety. Seattle-based retail chain Nordstrom has avoided opening its doors on Thanksgiving throughout the company?s history and in recent years has posted signs in its stores that read, ?One holiday at a time.?
Nordstrom waits until the morning of Black Friday to unveil its Christmas decorations, though it will open doors early that morning in some locations.
?It?s not as in your face,? said Forrester vice president and senior analyst Sucharita Mulpuru, ?but there?s a reason that Thanksgiving weekend that people work longer hours and [the stores] pull out all the stops as far as offering sales and promotions?because that?s the nature of that weekend.?
Analyst Greg Girard of IDC said?Black Friday is virtually absent from the websites of brand-oriented stores like Gap, Nordstrom and Lord & Taylor.
"And they?re doing something much more surgical in that they?re moving towards direct communications, like text messaging to consumers," he said. "They?re getting to consumers with whom they have a longer lifetime relationship."
Nordstrom, like many higher-end stores, doesn?t rely as heavily on Black Friday to make or break its sales year. Black Friday ?is among our most high volume days. But it isn?t our largest sales day of the year, unlike many retailers,? said Nordstrom spokesman Colin Johnson.
Do you plan to shop Black Friday?
With some major chains opening the doors on Thanksgiving for "Black Friday" sales, retail employees are beginning to publicly complain about sales creeping into their Thanksgiving holiday. KNSD's Bob Hansen reports.
?
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SAN JOSE, Calif. - Dan Henderson has put on some amazing shows over the years, but Saturday night may have been his best.
In a all-time classic fight, Henderson stumbled to the finish line, but he did so much heavy damage over the first three rounds that he earned a unanimous decision victory, 48-47 on all scorecards, over Mauricio "Shogun" Rua in the main event of UFC 139 at the HP Pavilion.
During the post-fight interview in the Octagon, UFC analyst Joe Rogan said the bout was one of the greatest MMA fights in history. UFC president said it was one of the top three fights he'd ever seen. It just might have been.
"I hit him on hard. Cut him a few times. I should've had him finished there, but the gas tank got me. He stayed in there with a great heart like a champion should," Henderson, who was being held up by one of his cornerman, told Rogan.
Both fighters escaped terrible predicaments and landed shots that would've finish most opponents at light heavyweight. They both held on and survived in those situations.
It was a tale of two fights. Henderson (29-8, 6-3 UFC) had Rua in trouble in each of the first three rounds. His jackhammer right hands nearly closed Rua's left eye after just 15 minutes. Henderson outlanded Rua 106-66 over the first three.
"That guy can take an [expletive] punch. I hit him hard tonight. I tried to finish him the first three rounds," said Henderson.
That's when the championship rounds arrived. Earlier this year, the UFC decided to make all main events, title and non-title fights, five rounds.
Henderson, 41, spent so much energy trying to pound out Rua that he was exhausted in the fourth and fifth. Rua almost took him out in the fourth. Henderson stumbled around the cage over the final 90 seconds of the round with his hands down by his sides.
In the fifth, Rua scored a takedown with 4:25 left in the fight and Henderson never got back up. Rua mounted Henderson several times. He outlanded Henderson 84-19 down the stretch.
Cagewriter scored the final round 10-8 for Rua, but none of the judges did. If they had, their scores would have matched the 47-47 we had as the final outcome.
The fight opened on a blistering pace. Henderson dropped Rua with a punch just over two minutes in. That was the first sign of a cut next to Rua's left eye. He bounced back in the final 80 seconds by bouncing a right off the top of Henderson's head that dropped the old guy.
Henderson pressed the attack in the second. Both fighters landed good shots, but Henderson produced the heavier blows.
Rua (20-6, 4-4 UFC) came out for the third with his eye slowly closing. Henderson put together a brilliant inside leg kick-right hand combination that dropped Rua again with 3:23 left in the round. Henderson went ballistic with elbows and punches on top of the Brazilian. Rua rolled to his side to cover up and the fight was seconds away from being stopped by referee Josh Rosenthal. He didn't step in and it was absolutely the correct decision.
Rua actually mounted a bit of a comeback in the final 33 seconds as he hurt a weary Henderson with a nice combination. Henderson said afterwards he thought he'd jumped out to a safe lead.
"I knew I had the first three rounds easily. I thought I even had one of the rounds 10-8," said Henderson.
Both fighters came out for the fourth taking deep breaths. Rua scored two momentary takedowns and Henderson drove through a big double leg takedown of his own with 3:46 left. With just over two minutes left, Henderson actually dropped his hands from sheer exhaustion. That's when Rua landed his best punch of the fight, a brutal uppercut that put Henderson on rubber legs. The veteran was out on his feet, he stumbled backwards and ate several more big shots.
Rua could've pushed Henderson to the ground without much resistance, but he was simply too tired to press forward over the next 45 seconds. He scored a takedown with 36 seconds left, mounted Henderson and took his back, but ran out of time as he looked for a choke.
The fifth round was an absolute whitewash for Rua. He took Henderson down 35 seconds into the round, mounted him three times and attempted a total of 97 strikes.
According to FightMetric, Rua outlanded Henderson 79-8 in the final round. For the entire fight, Rua outlanded Henderson 191-113. He also made good on 5-of-10 takedowns.
"I was confident before the decision was announced. I would have been very surprised if that decision did not go my way. If I didn't think I had the fight won, I would have tried to get on my feet that last round. He did do a good job of staying on top. He tucked his head in nice," said Henderson.
Henderson said his next fight should be for the UFC title.
"I want the 205-pound title and think I should be next in line for a shot."
White said Henderson is a candidate for a title shot at both middleweight and light heavyweight. He won't forced Henderson into one or the other. It'll be up to the fighter and what opportunity presents itself first.
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A new look at geologic evidence shows that the Gulf of California, the sea that separates the Baja California peninsula from mainland Mexico, formed in as little as 6 million to 10 million years ? much faster than most other ocean basins across the globe.
Six to 10 million years may sound like an eternity, but geologically speaking, it's the blink of an eye. Large basins, such as the Atlantic Ocean, can rift for 30 million to 80 million years before the crust ?completely ruptures, spilling magma and beginning the process of sea-floor spreading.
But the Gulf of California completed this act in near-record time, ?thanks to that old real estate motto: location, location, location. ?
Northern Arizona University geologist Paul Umhoefer said that the sea's rapid formation is likely due to its location along a tectonically active continental margin (the area where thin ocean crust meets thick continental crust) with three key characteristics: a hot, weakened crust, rapid plate motion, and strike-slip faulting (the side-by-side rubbing of plates along a fault).
Three keys
Umhoefer's study, detailed in the November issue of the journal GSA Today, arrived at those three factors based on findings by geologists and marine geophysicists working in the region over the past decade.
First, the continental margin inherited a swath of hot, weak crust from a volcanic chain that was active in the area around 12 million years ago, immediately before Baja California began to pull away from mainland Mexico.
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Science editor Alan Boyle's Weblog: Rotifers have been the big wheels of the microscopic world for 300 years, so it's fitting that a rotifer's wheel-like head gets its turn in the photographic spotlight.
"We know that a great deal of heat, or something like a volcanic chain, almost always contributes to a weaker crust," Umhoefer told OurAmazingPlanet. Weaker crust is, of course, easier to break.
This region of hot, weak crust straddled two relatively fast-moving plates: the Pacific plate and the North American plate, which pull diagonally away from each other at a rate of about 50 millimeters per year. That's on the higher end of average plate speeds, Umhoefer said. ( Tectonic plates typically move at a rate similar to fingernail growth ? anywhere from about 10 to 100 millimeters per year.)
"The faster the two plates move away from each other, the higher the overall rate of faulting, and the more likely the faults will be focused into a single boundary that eventually thins and ruptures the crust," Umhoefer said.
Finally, strike-slip faulting (as happens perhaps most famously along the San Andreas Fault) is common in the region and likely to have played a major role in rupturing the Gulf of California.
"Strike-slip faults by nature are steep" ? commonly near-vertical ? "so they have a tendency to cut efficiently through the crust and into the mantle," which focuses the breaking along very narrow zones, Umhoefer explained.
Altogether, his study concluded, these assets combined to rift and rupture the Gulf of California at a rapid pace.
Rifting worldwide
Globally, these factors also account for stark differences between rifts at active continental margins and those in the middle of a continent, Umhoefer said.
Areas that are tectonically active before rifting begins ? which usually lie at continental margins ? rupture rapidly and form smaller seas, such as the Gulf of California, because they rift off small pieces of continent. Rifts that begin in the middle of a continent slowly rupture and form larger basins, as in the case of the formation of the Atlantic Ocean, because they tend to break off large chunks of continental crust.
"How do continents that have active tectonics, like western North America, respond to rifting versus a place that's been relatively quiet? That's a question the research community is trying to answer," Umhoefer said.
? 2011 OurAmazingPlanet. All rights reserved. More from OurAmazingPlanet.
Source: http://www.msnbc.msn.com/id/45342610/ns/technology_and_science-science/
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